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    TLC502

    LNP siRNA protease inhibitor

    Description

    LNP siRNA protease inhibitor to prevent cartilage degradation

    Development Status

    Preclinical

    Advantages

    • Decrease collagen degradation
    • Decrease aggrecan degradation
    • Reduce inflammation
  • Overview
  • Overview

    TLC502 is a novel nucleic acid drug developed by TLC BioSciences, utilizing RNA interference (RNAi) mechanisms combined with lipid nanoparticle (LNP) technology to target genes associated with osteoarthritis. It is engineered to reduce the degradation of collagen and aggrecan, key components of cartilage, functioning as a sustained protease inhibitor. This innovative approach aims to preserve joint integrity and slow the progression of osteoarthritis, offering a new hope for patients seeking to maintain joint health and mobility.

    Indication

    Preclinical
    Phase 1
    Phase 2
    Phase 3
    NDA
    Market

    Cartilage preservation

    Preclinical ongoing